455 AD
Thirty-five years after the Visigothic sack, the Vandals under King Genseric sailed from North Africa and sacked Rome for two weeks. Unlike the Visigoths, who had been restrained by Bishop Germanus, the Vandals showed no mercy. They stripped the palace of the Caesars of its gold and silver, including tearing the golden mosaic from the Temple of Jerusalem that adorned the roof. The word 'vandalism' comes directly from this event.
The Vandal sack was particularly devastating because it came as the Western Roman Empire was already in terminal decline. The legitimate Western emperor, Valentinian III, had been assassinated just months before. The Church, under Pope Leo I (the Great), would become the de facto governing authority in Rome during the power vacuum that followed.
The Vandals were Arian Christians (rejecting the Trinity), and their kingdom in North Africa would become a center of Arianism and persecution of Catholics for over a century, until St. Augustine's homeland was reclaimed by the Byzantine general Belisarius in 533 AD. Key Sources: Procopius, History of the Wars; St. Leo the Great's Sermons; Vandal King Genseric's letters