1618-1648 AD
The Thirty Years' War (1618-1648) was the most destructive conflict in European history before the 20th century, killing an estimated 4-8 million peopleβperhaps a third of the population of the German states. It began as a religious war between Protestant and Catholic states within the Holy Roman Empire but evolved into a political struggle for dominance in Europe involving France, Spain, Sweden, Denmark, and the Habsburg emperors.
The war was triggered by the 'Defenestration of Prague,' when Protestant nobles threw two Catholic governors out of a window of Prague Castle. The conflict passed through four phases: the Bohemian Revolt, the Danish phase, the Swedish phase, and the French phase. By the end, the war had become so brutal that entire regions of Germany were depopulated, and armies lived off the land, starving and pillaging the civilian population.
The Peace of Westphalia (1648) ended the war and established the principle of cuius regio, eius religio (whose realm, his religion), effectively ending large-scale religious warfare in Europe. It also marked the decline of Habsburg power and the rise of France as the dominant European power. Key Sources: Peace of Westphalia; Friedrich Schiller, The History of the Thirty Years' War; Christopher Clark, Iron Kingdom